KMID : 0858420120140010035
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Korean Journal of Stroke 2012 Volume.14 No. 1 p.35 ~ p.42
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Aspirin Resistance May Not Be Associated with Clinical Outcome after Acute Ischemic Stroke: Comparison with Three Different Platelet Function Assays
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Yoo Nam-Tae
Bae Hyo-Jin Kim Ji-Eun Goh Ri-Young Han Jin-Yeong Kim Moo-Hyeon Cha Jae-Kwan
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Abstract
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Aspirin resistance (AR) in platelet function assays showed substantial variation depending on the methods used to evaluate it.
Methods: In this study, we prospectively compared the results of Multiplate impedance platelet aggregometry (IPA) with those of light transmission aggregometry (LTA) and VerifyNow¢ç system in determination of the prevalence of aspirin resistance (AR) and investigated the correlation between its presence and poor outcome (modifi ed Rankin scale >2) in 105 patients with aspirin after acute ischemic stroke (AIS).
Results: After 5 days of using aspirin, 15 patients (14.3%) were classified as aspirin-resistance with the use of IPA, 24 patients (22.9%) by the LTA, and 14 patients (13.3%) by VerifyNow. Good agreement between the results of IPA and VerifyNow, was found (R=0.674, P <0.01). The concordance rate of AR detection was high between VerifyNow and IPA (k=0.72, P <0.01), albeit quite low between LTA and IPA. Regarding on its infl uence on clinical outcome after AIS, there wasn¡¯t any signifi cant relationship between occurrence of poor outcome and the presence of AR in three platelet function assays.
Conclusion: This study reveals that the incidence of AR in AIS might be highly test-specifi c. IPA seems to be similar to VerifyNow as a platelet function test. (Korean J Stroke 2012;14:35-42)
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KEYWORD
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Aspirin resistance, Acute ischemic stroke, Platelet function test
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